Codeine vs. Oxycodone: A Comparison of Opioid Pain Relievers

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Both codeine and oxycodone are opioid pain medications used to treat moderate to severe pain, although they have different strengths, efficacy, and dependence potential. A gentler opioid that is frequently given for mild pain and cough suppression is codeine, which is frequently taken in combination with acetaminophen. Conversely, oxycodone is a more powerful opioid that relieves pain more effectively and is usually prescribed for more severe pain, including that which follows surgery or an injury.