Hemicholinium 3

Catalog No.GC64193
L'hémicholinium 3 est un inhibiteur compétitif du transporteur de choline de haute affinité (HACU) avec une valeur Ki de 25 nM.

Description
Hemicholinium 3 is a competitive inhibitor of the high-affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, is a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh)[1]. Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively[2].

Hemicholinium 3 (HC-3) inhibits the presynaptic nicotinic acetylcholine receptors of myenteric neurons. HC-3 inhibits nAChRs located on the terminal region of myenteric neurons of guinea-pig longitudinal muscle strip preparation[2]. Hemicholinium 3 (HC-3) inhibits[3H]choline uptake with the Ki value of 13.3 μM in NCI-H69 cells[3].HC-3 (1 mM) significantly inhibits cell viability and increases caspase-3/7 activity in NCI-H69 cells[3]. Hemicholinium 3 (Hemicholinium-3) inhibits sodium-dependent high-affinity choline uptake (IC50=18 nM)[4]. In vivo: Hemicholinium-3 impairs spatial learning. HC-3 (2.5, 5.0 μg/rat/ICV; 1 h before training) dose-dependently impairs spatial learning[5].

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