The Melanotan 2 injections usually stay in your system for six months. If you stop using Melanotan completely, your color will gradually fade just like a natural tan would. It should take about two to three months before your color is completely gone, about four weeks when Melanotan is not used. However, customers do not let it fade away completely and repeat the loading process by taking Melanotan 2 doses once or twice a week. It helps in maintaining color.