Intrathecal pharmacokinetics

The Intrathecal delivery of compounds acting on central nervous system (CNS) has enhanced interest due to the absence of continuous barriers between the cerebrospinal fluid (CSF) and CNS, which makes only fraction of CSF borne compounds delivered to the brain from the CSF through the perivascular channels. This is significant for macromolecules including biopharmaceuticals, for which the access to CNS from the systemic circulation is particularly hindered due to large molecular size and presence of several vascular barriers such as blood brain, blood-arachnoid and blood-CSF.
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